Well I don't have Blender, so for now at least I plan to try it by hand! But who knows. Maybe I'll give Blender a try. I think I've tried it in the past but got overwhelmed by all the things you could do with it. Maybe now is a good time to finally sit down and learn it!
Ohh that looks sick! I love games with this level of stylized horror like Doom and I'd even say Hades. Are you planning to use Blender or are you drawing the frames by hand?